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Original Article
- The effect of photodynamic therapy using Radachlorin on biofilm-forming multidrug-resistant bacteria
- Choong-Won Seo, Young-Kwon Kim, Jeong-Lib An, Jong-Sook Kim, Pil-Seung Kwon, Young-Bin Yu
- Osong Public Health Res Perspect. 2022;13(4):290-297. Published online August 10, 2022
- DOI: https://doi.org/10.24171/j.phrp.2022.0150
- 2,108 View
- 45 Download
- 4 Web of Science
- 4 Crossref
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Abstract
PDF - Objectives
This study aimed to test the effect of photodynamic therapy (PDT) on the inhibition and removal of biofilms containing multidrug-resistant Acinetobacter baumannii.
Methods
Using multidrug-resistant A. baumannii strains, an antibiotic susceptibility test was performed using the Gram-negative identification card of the Vitek 2 system (bioMérieux Inc., France), as well as an analysis of resistance genes, the effects of treatment with a light-emitting diode (LED) array using Radachlorin (RADA-PHARMA Co., Ltd., Russia), and transmission and scanning electron microscopy to confirm the biofilm-inhibitory effect of PDT.
Results
The antibiotic susceptibility test revealed multiple resistance to the antibiotics imipenem and meropenem in the carbapenem class. A class-D–type β-lactamase was found, and OXA-23 and OXA-51 were found in 100% of 15 A. baumannii strains. After PDT using Radachlorin, morphological observations revealed an abnormal structure due to the loss of the cell membrane and extensive morphological changes, including low intracellular visibility and small vacuoles attached to the cell membrane.
Conclusion
PDT involving a combination of LED and Radachlorin significantly eliminated the biofilm of multidrug-resistant A. baumannii. Observations made using electron microscopy showed that PDT combining LED and Radachlorin was effective. Additional studies on the effective elimination of biofilms containing multidrug-resistant bacteria are necessary, and we hope that a treatment method superior to sterilization with antibiotics will be developed in the future. -
Citations
Citations to this article as recorded by
- Photophysical properties of Radachlorin photosensitizer in solutions of different pH, viscosity and polarity
A.V. Belashov, A.A. Zhikhoreva, I.A. Gorbunova, M.E. Sasin, Sh.S. Shayakhmedov, I.V. Semenova
Spectrochimica Acta Part A: Molecular and Biomolec.2024; 305: 123480. CrossRef - Applications of Antimicrobial Photodynamic Therapy in Aquaculture: Effect on Fish Pathogenic Bacteria
Edith Dube, Grace Emily Okuthe
Fishes.2024; 9(3): 99. CrossRef - Understanding the biofilm development of Acinetobacter baumannii and novel strategies to combat infection
Naji Naseef Pathoor, Akshaya Viswanathan, Gulshan Wadhwa, Pitchaipillai Sankar Ganesh
APMIS.2024; 132(5): 317. CrossRef - PDT-Induced Variations of Radachlorin Fluorescence Lifetime in Living Cells In Vitro
Andrey V. Belashov, Anna A. Zhikhoreva, Anna V. Salova, Tatiana N. Belyaeva, Ilia K. Litvinov, Elena S. Kornilova, Irina V. Semenova
Photonics.2023; 10(11): 1262. CrossRef
- Photophysical properties of Radachlorin photosensitizer in solutions of different pH, viscosity and polarity
Corrigendum
- Corrigendum to “Epidemiological Characterization of Imported Systemic Mycoses Occurred in Korea” [Osong Public Health Res Perspect 2018;9(5):255–60]
- Seung-Hak Cho, Young-Bin Yu, Je-Seop Park, Keun-Dol Yook, Young-Kwon Kim
- Osong Public Health Res Perspect. 2018;9(6):362-362. Published online December 31, 2018
- DOI: https://doi.org/10.24171/j.phrp.2018.9.6.11
- 4,200 View
- 32 Download
Original Articles
- Epidemiological Characterization of Imported Systemic Mycoses Occurred in Korea
- Seung-Hak Cho, Young-Bin Yu, Je-Seop Park, Keun-Dol Yook, Young-Kwon Kim
- Osong Public Health Res Perspect. 2018;9(5):255-260. Published online October 31, 2018
- DOI: https://doi.org/10.24171/j.phrp.2018.9.5.07
- 10,731 View
- 122 Download
- 4 Crossref
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Abstract
PDF
Objectives Imported systemic mycoses is a severe fungal infection that can cause diseases in healthy people. However, there is a serious lack of epidemiological data about imported systemic mycoses. Therefore, an epidemiological characterization of imported systemic mycoses in Korea was performed.
Methods We collected health insurance data between 2008 and 2012 from the Health Insurance Corporation and analyzed the data to determine the prevalence and treatment management of imported systemic mycoses.
Results The prevalence of imported systemic mycoses between 2008 and 2012 increased slowly by 0.49/100,000 to 0.53/100,000 persons. The prevalence of coccidioidomycosis increased from 0.28/100,000 in 2008 to 0.36/100,000 persons in 2012. A mean of 229.6 cases occurred each year. Children and the elderly showed higher prevalence than adults in the 20- to 59-year-old age group. The rate of infection according to region ranged from 0.18/100,000 persons in Ulsan, to 0.59/100,000 persons in Gyeonggi. The prevalence in females was higher than that in males. Inpatient treatment was 3.3% (38 cases), with 96.7% treated as outpatients. Hospitalizations cost 272.7 million won and outpatient treatments cost 111.7 million won. The treatment cost for coccidioidomycosis from 2008 to 2012 was 330.9 million won, with personal charges of 79.2 million won and insurance charges of 251.7 million won. Most of the expenses for the coccidioidomycosis treatment were for inpatient treatment.
Conclusion The results in this study may be a useful resource for determining the changes in the trend of imported systemic mycoses.
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Citations
Citations to this article as recorded by- Invasive Fungal Infections in Acute Decompensation of Cirrhosis: Epidemiology, Predictors of 28-Day Mortality, and Outcomes
Yu Wang, Chen Li, Haibin Su, Jinhua Hu
Indian Journal of Microbiology.2024;[Epub] CrossRef - The clinical laboratory evolution in coccidioidomycosis detection: Future perspectives
José María Gastélum-Cano, Mitzuko Dautt-Castro, Alfonso García-Galaz, Katya Felix-Murray, Antonio Rascón-Careaga, Manuel A. Cano-Rangel, María A. Islas-Osuna
Journal of Medical Mycology.2021; 31(3): 101159. CrossRef Emerging Invasive Fungal Infections: Clinical Features and Controversies in Diagnosis and Treatment Processes
Hongliang Zhang, Aiqun Zhu
Infection and Drug Resistance.2020; Volume 13: 607. CrossRef- Timely Diagnosis of Histoplasmosis in Non-endemic Countries: A Laboratory Challenge
María José Buitrago, M. Teresa Martín-Gómez
Frontiers in Microbiology.2020;[Epub] CrossRef
- Invasive Fungal Infections in Acute Decompensation of Cirrhosis: Epidemiology, Predictors of 28-Day Mortality, and Outcomes
- Epidemiological Characterization of Skin Fungal Infections Between the Years 2006 and 2010 in Korea
- Sang-Ha Kim, Seung-Hak Cho, Seung-Ki Youn, Je-Seop Park, Jong Tae Choi, Young-Seok Bak, Young-Bin Yu, Young Kwon Kim
- Osong Public Health Res Perspect. 2015;6(6):341-345. Published online December 31, 2015
- DOI: https://doi.org/10.1016/j.phrp.2015.10.012
- 3,737 View
- 29 Download
- 11 Crossref
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Abstract
PDF
- Objectives
The purpose of this study was to build and provide a basic database of skin fungal infections for the effective management of skin fungal infections in the future.
Methods
We collected health insurance data between the years 2006 and 2010 from the Health Insurance Corporation (Seoul, Korea) and analyzed the data to determine the prevalence and treatment management of skin fungal infections.
Results
Skin fungal infections were divided into two groups: namely dermatophytosis and other superficial mycoses. Dermatophytosis showed a higher prevalence (16,035,399 cases) than the other superficial mycoses (794,847 cases) within the study period. The prevalence rate decreased consecutively by 0.01% to 0.19% every year. The prevalence according to region showed that Jeolla-do had a high prevalence distribution. The prevalences in men and women were similar (7.01% vs. 6.26%). It is interesting to note that adults from the 50–79-year age group showed a higher prevalence than children and young adults. The average convalescence time (days) of dermatophytosis was longer than that of other superficial mycoses. The total medical expenses were also much higher in dermatophytosis than in the other superficial mycoses.
Conclusion
This study provides useful data for study trends of skin fungal infections. -
Citations
Citations to this article as recorded by- Amphotericin B-loaded natural latex dressing for treating Candida albicans wound infections using Galleria mellonella model
Rondinelli Donizetti Herculano, Camila Eugênia dos Reis, Silvia Maria Batista de Souza, Giovana Sant'Ana Pegorin Brasil, Mateus Scontri, Satoru Kawakita, Bruna Gregatti Carvalho, Camila Calderan Bebber, Yanjin Su, Ana Paula de Sousa Abreu, Marvin M Mecwan
Journal of Controlled Release.2024; 365: 744. CrossRef - Microsurgical Debridement for Persistent Ulcers Due to Rare Fungus Infection: Case Report and Literature Review
Yu-Wen Tsui, Chia-Yu Tsai, Hung-Chi Chen
Archives of Plastic Surgery.2024; 51(01): 135. CrossRef - Prevalence and antifungal drug resistance of dermatophytes in the clinical samples from Pakistan
Bakhtawar Usman, Abdul Rehman, Iffat Naz, Muhammad Anees
Acta Microbiologica et Immunologica Hungarica.2021;[Epub] CrossRef - Discovery of a novel and selective fungicide that targets fungal cell wall to treat dermatomycoses: 1,3‐bis(3,4‐dichlorophenoxy)propan‐2‐aminium chloride
Daiane Flores Dalla Lana, Stefânia Neiva Lavorato, Laura Minussi Giuliani, Letícia Cruz, William Lopes, Marilene Henning Vainstein, Igor Camargo Fontana, Aline Rigon Zimmer, Murillo de Araújo Freitas, Saulo Fernandes de Andrade, Ricardo José Alves, Alexan
Mycoses.2020; 63(2): 197. CrossRef - Voriconazole-natural latex dressings for treating infected Candida spp. skin ulcers
Thainá V da Silva, Natan R de Barros, Caroline B Costa-Orlandi, Jean L Tanaka, Lincoln G Moro, Giovana S Pegorin, Kassandra SM Oliveira, Maria JS Mendes-Gianinni, Ana M Fusco-Almeida, Rondinelli D Herculano
Future Microbiology.2020; 15(15): 1439. CrossRef - The Pathogenesis of Fungal-Related Diseases and Allergies in the African Population: The State of the Evidence and Knowledge Gaps
Lorraine Tsitsi Pfavayi, Elopy Nimele Sibanda, Francisca Mutapi
International Archives of Allergy and Immunology.2020; 181(4): 257. CrossRef - Medicinal Importance of Azo and Hippuric Acid Derivatives
Tehreem Tahir, Muhammad Ashfaq, Humna Asghar, Mirza I. Shahzad, Rukhsana Tabassum, Areeba Ashfaq
Mini-Reviews in Medicinal Chemistry.2019; 19(9): 708. CrossRef - Evaluation of antifungal activity of blended cinnamon oil and usnic acid nanoemulsion using candidiasis and dermatophytosis models
Peeyush kumar, P.W. Ramteke, Avinash C. Pandey, Himanshu Pandey
Biocatalysis and Agricultural Biotechnology.2019; 18: 101062. CrossRef - A novel approach for skin infections: Controlled release topical mats of poly(lactic acid)/poly(ethylene succinate) blends containing Voriconazole
Neslihan Üstündağ Okur, Maria Filippousi, Mehmet Evren Okur, Şule Ayla, Emre Şefik Çağlar, Ayşegül Yoltaş, Panoraia I. Siafaka
Journal of Drug Delivery Science and Technology.2018; 46: 74. CrossRef - Serious fungal infections in Korea
K. Huh, Y. E. Ha, D. W. Denning, K. R. Peck
European Journal of Clinical Microbiology & Infect.2017; 36(6): 957. CrossRef - Epidemiology of Fungal Infections in Patients Admitted via Emergency Department in Korea (2011~2013)
서영우, 장태창, 박준수
Korean Journal of Medical Mycology.2016; 21(4): 111. CrossRef
- Amphotericin B-loaded natural latex dressing for treating Candida albicans wound infections using Galleria mellonella model
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